Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat

Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat

Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat

The kidney is centrally involved in blood pressure regulation and undergoes extensive changes during pregnancy. Hypertension during pregnancy may result in an altered urinary peptidome that could be used to indicate new targets of therapeutic or diagnostic interest. The stroke-prone spontaneously hypertensive rat (SHRSP) is a model of maternal chronic hypertension. Capillary electrophoresis-mas...

Stroke-Prone Spontaneously Hypertensive Rats

Background and Purpose We examined metabolic and functional changes when forebrain ischemia was induced in strokeprone spontaneously hypertensive rats by bilateral carotid artery occlusion. In addition, the protective effect of clentiazem was evaluated in this model. Methods Rats were anesthetized with urethane. Cerebral blood flow was measured with a laser Doppler fkrwmeter. Cerebral high-ener...

Hypertensive changes in intratesticular arteries impair spermatogenesis of the stroke-prone spontaneously hypertensive rat.

It is reported that some elderly males exhibit both hypospermatogenesis and intratesticular arterial changes. These arterial changes are thought to contribute to spermatogenic damage. In this study the process of the damage to spermatogenesis induced by such changes was evaluated using stroke-prone spontaneously hypertensive rats (SHRSP). SHRSP showed a rapid increase of blood pressure, followe...

Impaired functional recovery after stroke in the stroke-prone spontaneously hypertensive rat.

BACKGROUND AND PURPOSE To identify if the stroke-prone spontaneously hypertensive rat (SHRSP) exhibits impaired functional recovery after stroke compared with its normotensive reference strain, the Wistar Kyoto rat (WKY). METHODS In study 1, a 2-mm distal middle cerebral artery occlusion (middle cerebral artery occlusion) was performed in both strains and recovery assessed using a 33-point ne...